DCCT-EDIC.ORG

The landmark DCCT study (1983-1993) demonstrated the benefits of intensive therapy aimed at near normal glycemia versus conventional therapy (as practiced in 1982) in reducing the risk of microvascular complications in 1,441 subjects with T1D over a mean follow-up of 6.5 years. The EDIC study (1994-present) is the observational follow-up study of the DCCT cohort. The overarching goal of the EDIC study is to continue to assess the long-term effects of intensive versus conventional therapy on microvascular and cardiovascular complications. The EDIC study has notably shown that the early beneficial effects of intensive blood glucose control on diabetes-related complications have persisted for more than 20 years despite similar HbA1c levels in the two groups during EDIC, termed metabolic memory. Former intensive therapy also greatly reduced the risk of cardiovascular events, advanced microvascular complications such as chronic kidney disease and eye complications requiring surgery, and..

Primary location: Rockville United States