Both the RNA imaging approach and the virtual reality approach are being applied to the problem of varying levels of MAOA mRNA and D2DR mRNA in certain brain cells that react strongly to cocaine. We are developing mRNA imaging agents to visualize and quantitate those two neural mRNAs in vivo. Similarly, we are developing mRNA imaging agents that target the NLGN4Y mRNA, which might be implicated in the development of autism spectrum disorders, when overexpressed. Finally, we have designed PNA sequences targeting HTT mRNA, for PET imaging of the efficacy of antisense therapy in Huntington's disease.
Also known as: mRNA, mRNAs