ARMACHE LAB

The Armache lab is interested in understanding the mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in genome regulation. The genome in eukaryotes is organized into chromatin, a condensed superstructure that evolved to keep DNA protected from damage and to tightly control gene expression. The basic unit of chromatin is the nucleosome, an octamer of proteins called histones wrapped by DNA. Cells evolved chromatin regulators to control critical steps in development and differentiation through processes such as DNA methylation, post-translational histone modifications, ATP-dependent remodeling, and mechanisms that establish a specific chromatin state. To this end, histones contain elongated tails that can be post-translationally modified. This is established, maintained, and interpreted mainly by non-histone chromosomal proteins. In turn, ATP-dependent chromatin remodelers modulate DNA accessibility by repositioning DNA with respect to the histones..

Primary location: University Park United States