MCGUIRE

In this issue, thousands of longitudinally measured chemical and biological components along with physical factors in the personal exposome cloud were investigated for their impact on internal -omes, such as the proteome, metabolome, gut microbiome, as well as cytokines and blood markers. On the cover, the dynamic and diverse exposomics profile is depicted as a mixture and its complex interactions with the gut microbiome and internal biomolecules in various organs is illustrated. These potential gene-environment interactions elucidate how the exposome shapes human phenome and impacts precision health. (Cover artwork by Lettie McGuire [https://lettiemcguire.com]. [For details, see Gao et al... Stanford Healthcare Innovation Lab is building the future of precision medicine at the intersection of computer science and biology.