CAMBRIDGE BRC - Key Persons
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- Senior Group Leader and Director Emeritus at the Wellcome Trust Sanger Institute
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- Academic Lead for Infectious Disease, BRC CHERUB Collaborator
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- Director of Operations and Principal Scientist, Phenotyping Hub
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- Group Leader at MRC - LMB, Cambridge, UK
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- Professor of Molecular Nutrition and Metabolism, European Research Council Investigator, Honorary Consultant in Metabolic Medicine
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- Chairman of Gastroenterology
- Theme Lead for Gastrointestinal Disease
Professor Arthur Kaser is the University Chair of Gastroenterology and Honorary Consultant at the University of Cambridge and Cambridge University Hospitals. He qualified from Leopold Franzens University Innsbruck and held earlier positions in Innsbruck and in Boston at Brigham and Women's Hospital & Harvard Medical School. Arthur's laboratory studies the mechanisms causing inflammatory bowel disease, and has made major contributions into our understanding of genetically-affected pathways at the host - environment interface. His research is supported by the Wellcome Trust and the European Research Council (ERC). In addition to fundamental research into disease mechanisms, Arthur also explores new treatment targets through experimental medicine- and early phase clinical trials. Arthur chairs the Cambridge Immunology Strategic Network, and is Course Co-Director of the Cambridge-MedImmune PhD Programme. He serves as Associate Editor of GUT, and chairs the Research Board of United European Gastroenterology (UEG).
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- Professor of Clinical Neuropsychology
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- Bernard Wolfe Professor of Health Neuroscience
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- Senior Research Associate
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- Director of Cambridge Institute of Public Health
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- Professor of Experimental Medicine
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- Professor of Biophysical Chemistry
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- Professor and Head of Paediatrics at University of Cambridge
David Rowitch is Professor and Head of Paediatrics at University of Cambridge, and he holds a joint appointment at UCSF (Pediatrics and Neurological Surgery). He trained at UCLA Medical School, University of Cambridge and Boston Children's Hospital, Harvard Medical School. Professor Rowitch is a neonatologist and neuroscientist whose laboratory investigates genetic factors that determine development and diversity of glial cells of the brain and the response to injury. He has applied these principles to better understand white matter injury in premature infants, brain cancer and leukodystrophy. Rowitch lead the first human clinical trial of direct neural stem cell transplantation focused on the rare and fatal leukodystrophy, Pelizaeus-Merzbacher Disease. His work in the field of neurobiology has earned him numerous awards. He became a Howard Hughes Medical Institute Investigator in 2008 and Professor of Paediatrics at Cambridge University and Wellcome Trust Senior Investigator in 2016. His interest in precision medicine focuses on applications of genomic technologies to diagnose and better understand the biological basis and rational treatment of rare neurological disorders.
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- Professor of Molecular Neurogenetics
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- Head of NIHR BRC Nutritional Biomarker Laboratory
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- Senior Scientist at the European Molecular Biology Laboratory - European Bioinformatics Institute. Lead Cambridge BRC EBPOD Fellowship Scheme
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- Senior Research Associate
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- Honorary Consultant and University Lecturer in ICU / Dept Director of Clinical Academic Training and Director of Academic Clinical Fellow Programme
Dr Ed Wilson is a senior researcher in health economics at the Cambridge Clinical Trials Unit.
He explains how his work helps decide which new treatments should be delivered in the NHS.
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- Clinical Director in Infectious Diseases
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- NHS Blood and Transplant Principle Investigator
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- Clinical Lecturer in Microbiology and Senior Research Associate
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- Wellcome Trust Senior Research Fellow
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- Honorary Consultant Radiologist
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- Reader in Reproductive Immunology
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- Honorary Consultant
- Wellcome Senior Clinical Research Fellow
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- Clinical Research Career Development Fellow
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- Wellcome Trust Intermediate Clinical Fellow
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- Associate Lecturer in Medicine and Consultant Physician in Clinical Pharmacology
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- Reader in Metabolic Bone Disease and Honorary Consultant Rheumatologist
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- Senior Nutritional Biomarker Specialist
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- Senior Research Associate
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- Senior Research Associate
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- Reader in Diabetic Medicine
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- Honorary Consultant and University Lecturer
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- Consultant Clinical Scientist
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- Honorary Consultant
- Theme Lead
- University Lecturer in Transplantation Medicine
Dr Menna Clatworthy is a University Lecturer at the University of Cambridge and an Honorary Consultant Nephrologist. Whilst a nephrology trainee at Cambridge she undertook a PhD in the Department of Medicine and won the British Renal Association Raine Award and the MRS/AMS Young Investigator award for this work. She subsequently completed a Wellcome Trust Intermediate Fellowship, working in Cambridge and the National Institutes of Health, Bethesda, USA. Menna took up her current post in 2012 and her research focuses on the generation and effector function of antibodies and their targeting in kidney transplantation and kidney-specific immunity. Dr Clatworthy teaches and mentors students/trainees in her roles as Director of Studies at Pembroke College, Director of the NIH-OxCam PhD Programme, and Director of the MPhil in Clinical Sciences (Genetics and Rare Diseases).
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- Head of Stable Isotope Laboratory
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- Senior Lecturer in Reproductive Biology
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- Wellcome Trust Senior Clinical Fellow
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- Director of Research ( Clinical )
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- Honorary Consultant and BHF Senior Research Fellow
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- Senior Research Associate
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- European Research Council Investigator
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- Honorary Consultant Radiologist
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- Senior Nutritionist - Projects
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- Honorary Consultant Radiologist
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- Clinical Lecturer in Microbiology
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- Senior Research Associate
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- Academic Clinical Consultant
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- Reader in Thoracic Oncology and Honorary Respiratory Physician
- Senior Clinical Researcher in Thoracic Oncology
Ed Bullmore trained in medicine at the University of Oxford and St Bartholomew's Hospital, London; then in psychiatry at the Bethlem Royal & Maudsley Hospital, London. He moved to Cambridge as Professor of Psychiatry in 1999 and is currently Co-Chair of Cambridge Neuroscience, Scientific Director of the Wolfson Brain Imaging Centre, and Head of the Department of Psychiatry, in the University. He is also an honorary Consultant Psychiatrist and Director of R&D in Cambridgeshire & Peterborough Foundation NHS Trust; and, since 2005, he has worked half-time for GlaxoSmithKline, currently focusing on immuno-psychiatry. He has published more than 500 scientific papers and was listed by Thomson Reuters (2016) as one of the top 1% most highly cited scientists globally in Neuroscience & Behaviour and in Psychology & Psychiatry.
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- Wellcome - Beit Intermediate Fellow
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- Senior Research Associate in the Department of Haematology
Ernest Turro is a Senior Research Associate in the Department of Haematology at the University of Cambridge with an interest in rare diseases.
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- Professor of Endocrine Physiology, Wellcome Trust Investigator, Honorary Consultant in Clinical Biochemistry
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- Wellcome Trust Senior Investigator
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- Director of PET ( Radiochemistry ) Sciences and Professor of Molecular Imaging Chemistry
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- Wellcome Trust Intermediate Clinical Fellow
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- Group Leader at the Wellcome Trust Sanger Institute
- Professor
Professor Gordon Dougan, Ph.D., - Professor Dougan is a group leader at The Wellcome Trust Sanger Institute (WTSI) and a Professor in the Department of Medicine at Cambridge University. He also holds adjunct professorships at the Universities of Monash and Melbourne. His personal research team studies enteric pathogens with a strong emphasis on pathogenic mechanisms, genomics and immunology. He has a particular interest in using genomics to study the evolution of Salmonella enterica serovar Typhi, the cause of typhoid. Before moving to the WTSI he was the founding Director of the Centre for Molecular Microbiology and Infection at Imperial College London and a Professor of Biochemistry. He is a member of EMBO and a Fellow of the Royal Society. He received his B Sc and Ph.D. from the University of Sussex and conducted postdoctoral studies at the University of Washington (Seattle) in the laboratory of Stanley Falkow. He worked in industry developing novel vaccines at an internationally renowned multi-national company and is an expert in vaccinology.
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- Professor and Head of the Department of Obstetrics
Gordon Smith is Professor and Head of the Department of Obstetrics and Gynaecology, University of Cambridge, UK. He has five degrees from Glasgow University. His clinical training was in Glasgow, including sub-specialist training in Maternal-Fetal Medicine. He had Wellcome Trust clinical research training fellowships based in Glasgow University (1992-1993) and Cornell University, USA (1996-1999). His clinically orientated research focuses on using maternal, ultrasonic and biochemical data to predict adverse pregnancy outcome. He was elected a Fellow of the Academy of Medical Science in 2010.
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- Professor of Stroke Medicine
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- Wellcome Trust Intermediate Clinical Fellow, Honorary Consultant Gastroenterologist
- Wellcome Trust Intermediate Fellow
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- Professor, Honorary Consultant
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- Professor of Epidemiology and Medicine at the University of Cambridge
Professor John Danesh trained in medicine at the University of Otago in New Zealand and at the Royal Melbourne Hospital in Australia. During his time as a Rhodes scholar, he received an MSc in Epidemiology at the London School of Hygiene and Tropical Medicine and a DPhil in Epidemiology at the University of Oxford. He was elected a Fellow of the Royal College of Physicians in 2007.
Since 2001, Danesh has been the Professor of Epidemiology and Medicine at the University of Cambridge. He holds a British Heart Foundation Professorship, a European Research Council Advanced Investigator Award, and an NIHR Senior Investigator Award.
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- Professor of Old Age Psychiatry
- Professor of Old Age Psychiatry and Honorary Consultant Psychiatrist
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- Physical Activity Specialist
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- Head of the Department of Medicine at the University of Cambridge
- Professor of Medicine, Head of Department, Wellcome Trust Investigator
Ken Smith is Professor of Medicine and Head of the Department of Medicine at the University of Cambridge, United Kingdom. His laboratory studies basic immunological mechanisms and how defects in regulatory control of the immune system can lead to autoimmunity and alter defence against infection. The lab also runs a translational program in autoimmune disease (particularly SLE, vasculitis and IBD) and has led to the discovery of a prognosis-predicting biomarker entering clinical trials and the identification of new pathways driving disease outcomes in autoimmunity and infection. By integrating human and animal studies and using state-of-the-art bioinformatic methodology, the laboratory can explore immunological mechanisms that are relevant to human disease, and to translate these results into applications of direct benefit to patients.
Ken trained in nephrology and clinical immunology with an interest in autoimmune disease at the University of Melbourne, Australia. His PhD at the Walter and Eliza Hall Institute examined aspects of B cell immunology. He moved to Cambridge in 1996.
He was elected a Fellow of the Academy of Medical Sciences in 2006, and he was awarded the Lister Institute Research Prize in 2007 and the Distinguished Investigator Award of the Lupus Research Institute in 2013.
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- Tenured Principal Investigator, MRC Laboratory of Molecular Biology
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- Professor of Immunology and Infectious Diseases
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- Professor of Medical Genetics and Neurodevelopment at the University of Cambridge
Lucy Raymond is Professor of Medical Genetics and Neurodevelopment at the University of Cambridge and Honorary Consultant in Medical Genetics at Cambridge University Hospital, Cambridge Biomedical Campus, UK. Her research interest is understanding the genetic basis of intellectual disability and has identified disease causing genes over the years which have been rapidly translated into clinical service. She is a leader of large collaborative efforts to identify the remaining causes of rare disease genes where intellectual disability, epilepsy or neurological conditions predominate. She is currently Assistant Director of the UK NIHR Rare Diseases Bioresource and Director of the East of England Genomics Medicine Centre that is delivering the 100K Genome Project for Rare Disease and Cancer.
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- Professor of Regenerative Medicine Affiliated to the Department of Surgery Cambridge University
Ludovic Vallier is Professor of Regenerative Medicine affiliated to the Department of Surgery Cambridge University, Senior Group Leader jointly based at the Medical Research Council (MRC) and Wellcome Trust Cambridge Stem Cell Institute and the Welcome Trust Sanger Institute, and director of the NIHR Cambridge Biomedical Research Centre human Induced Pluripotent Stem Cells core facility. His group employs human pluripotent stem cells and organoid as in vitro models to uncover molecular mechanisms controlling early cell fate decisions in human development. These studies have uncovered key factors controlling differentiation of pluripotent cells into endoderm progenitors from which the pancreas, lung, gut and liver originate. His group exploits the resulting cells to study inherited metabolic diseases and to develop regenerative medicine applications. Thus, his overall objective is not only to acquire the knowledge necessary to control differentiation of stem cells into specific endodermal cells but also to generate cell types for clinical studies of metabolic disorders and for cell based therapy.
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- Professor of Molecular Neurology
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- Principle Research Associat
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- MRC Clinical Research Training Fellow
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- Programme Leader, MRC Laboratory of Molecular Biology
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- Consultant Hepatologist, Director NAFLD Service`
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- Consultant Gastroenterologist
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- Lecturer in Transfusion and Transplant Virology
Professor Nick Morrell, FMedSci, is the British Heart Foundation (BHF) Professor of Cardiopulmonary Medicine, NIHR Senior Investigator, interim Director of the planned Cambridge Heart and Lung Research Institute, Director of the BHF Cambridge Centre for Cardiovascular Research Excellence and Research Director of the National Pulmonary Hypertension Service at the Royal Papworth Hospital. His research has focused on understanding molecular mechanisms of pulmonary arterial hypertension (PAH) caused by mutations in the bone morphogenetic protein type II receptor (BMPR-II), and leading national and international genetic studies of PAH. He has developed novel therapeutic approaches that target the BMPR-II signaling pathway. He has published over 200 papers in this field. He was elected to the Fellowship of the Academy of Medical Sciences in 2011. He is Editor-in-Chief of the journal, Pulmonary Circulation. He has served on research grant committees for the BHF, Medical Research Council and Wellcome Trust. He leads a research team with expertise that ranges from genetics, stem cells, drug discovery, preclinical models of disease, to experimental medicine studies in patients.
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- Co - Director of the University of Cambridge Institute of Metabolic Science
Nick Wareham is Co-Director of the University of Cambridge Institute of Metabolic Science, Director of the Medical Research Council (MRC) Epidemiology Unit and the Centre for Diet and Activity Research (CEDAR - a UKCRC Centre of Excellence in Public Health). He leads research on the interplay between genetic, lifestyle and developmental risk factors in the aetiology of obesity, diabetes and related metabolic conditions and individual and population-level approaches to prevention of non-communicable diseases.
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- Wellcome Trust Career Re - Entry Fellow, Honorary Consultant Physician
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- Bernard Wolfe Professor of Health Neuroscience
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- Principal
- Research Associate
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- Wellcome Trust Principal Research Fellow
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- Senior Research Associate
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- Programme Director - Measurement and Surveys
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- Wellcome Trust Senior Investigator
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- Honorary Consultant and Head of Department of Surgery
- Honorary Consultant Director of Academic Foundation Programme
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- Professor of Clinical Nursing Research
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- Professor of Metabolism and Medicine
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- Honorary Consultant Lead, Experimental Medicine Training for Clinicians
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- Professor of Molecular Virology
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- Honorary Consultant Director of Wellcome Trust Clinicians PhD Programme, Cambridge
- Professor of Endocrinology at the University of Cambridge
Krishna Chatterjee is Professor of Endocrinology at the University of Cambridge. His research, encompassing genetic disorders of the pituitary thyroid axis and nuclear hormone synthesis and action, has been funded continuously for over 25 years by the Wellcome Trust. Support from the NIHR Cambridge Biomedical Research Centre translates his discoveries into a national diagnostic service for rare and unusual thyroid disorders.
As Director of the Addenbrooke's and NIHR Cambridge Clinical Research Centres (2002-ongoing) and Deputy Director of the NIHR Cambridge Biomedical Research Centre, he has played a key role in developing and managing NIHR Clinical Research Facilities, which conduct translational research and experimental Medicine, on the Cambridge Biomedical Campus.
He also directs the Wellcome Trust PhD for Clinicians programme in Cambridge (2012-ongoing), mentoring a diverse cohort of clinical medical and veterinary fellows to make an informed choice of doctoral research and then guiding their development along the clinician-scientist pathway.
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- Honorary Consultant Director of Wellcome Trust Infection and Immunity PhD Programme, Cambridge
- Professor Immunology, Honorary Consultant
Professor Richard Gilbertson is the Li Ka-shing Professor of Oncology, Head of the Department of Oncology and Director of the Cancer Research UK Cambridge Centre.
He trained as a pediatric oncologist in the UK where he earned his MBBS and PhD degrees, becoming a member of the Royal College of Physicians in 1995. He moved to St Jude Children's Research Hospital, Memphis, Tennessee, USA in 2000 where he served as the Co-Leader of the Neurobiology and Brain Tumor Program and founding Director of the Molecular Clinical Trials Core, before being appointed as the Comprehensive Cancer Center Director, Executive Vice President, and Lillian R Cannon Endowed Chair in 2011. In 2014 he was appointed as the Scientific Director of St Jude Children's Research Hospital.
In August 2015, he moved back home to England to take up his current positions at the University of Cambridge. His laboratory research is focused on understanding the link between normal development and the origins of cancer, particularly brain tumours.
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- Consultant Clinical Geneticist
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- Programme Leader, Memory and Perception Group
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- Professor of Clinical Neuroscience at the University of Cambridge
Roger Barker is the Professor of Clinical Neuroscience at the University of Cambridge and Consultant Neurologist at the Addenbrooke's Hospital Cambridge.
His research seeks to better define the clinical heterogeneity of two common neurodegenerative disorders of the central nervous system- namely Parkinson's (PD) and Huntington's disease (HD). This he has done by collecting large cohorts of incident cases and following them over time using an array of investigational and assessment tools.
In addition he has been heavily involved in gene and cell based trials for patients with these conditions and currently co-ordinates an EU funded transplant programme using human fetal tissue for patients with PD, following on from an earlier MRC funded trial using a similar approach in HD. He is part of a new EU project (NeuroStemCellRepair) and a global initiative (GFORCE-PD) that is seeking to take stem cells to trial in these disorders.
He is currently is Co-Editor in Chief of the Journal of Neurology and sits on the editorial board of many other journals. He has just stepped down as the chairman of the ERC Neuroscience Advanced Grants board, and is on the research advisory board of the Cure PD Trust and Parkinson's UK.
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- Lecturer in Clinical Informatics
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- Wellcome Trust Intermediate Fellow
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- Professor of Developmental Psychopathology
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- Director of the MRC Biostatistics Unit and Senior Research Fellow
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- Professor of Child and Adolescent Psychiatry
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- Senior Clinical Research Fellow
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- Professor of Cognitive Neuroscience and Experimental Psychology
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- Senior Research Associate
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- Professor
- Van Geest Professor of Neuroscience