TRK MUTATIONS

We are a group of scientists interested in TRK mutations and their importance in human cancer therapeutics... In panel D we have a T → G substitution in the third nucleotide in the lysine (K) codon. What we get is another lysine due to the degeneracy of the genetic code. This is called a silent as well as a synonymous mutation. Not all point mutations are even remotely bad. Some do not change any aspect of the business of the cell... Genetic alterations that result in "fusion proteins" are sometimes more dangerous than simple genetic code Trk mutations.