BIOPHOTONICS.TECH

In Nanophotonics and Biodetection Systems (NBS) Laboratory, we are developing medical technologies for improving public health and fundamental research in biology and pharmacology... Detection of clinical functional response in a patient following treatment initiation is currently measured indirectly by imaging or direct measurement of tumor burden. However, these assessments are slow and clinical indicators are only useful for making post-hoc treatment decisions. In the ideal scenario, therapeutic functional assays would be used to guide selection of treatment that would induce response and thereby avoid problematic side effects from inefficacious therapies. A straightforward approach for assaying single cell growth would be to seed individual cells in wells and monitor proliferation before and after delivery of a drug by microscopy. While this would be an improvement over bulk assays, a statistically robust proliferation assay requires large sample sizes and several cell doublings...