DELIVER THERAPEUTICS

Cellular senescence is characterized by irreversible cell cycle arrest and a proinflammatory senescence-associated secretory phenotype (SASP), which is a major contributor to aging and age-related diseases. Senescent cells accumulate during aging and negatively influence lifespan and promote age-dependent changes in several organs. IL-1, IL-6, IL-8, TNF-α, TGF-β, and various matrix metalloproteinases (MMP3, 12) make up the key components of the SASP. The sustained inflammatory microenvironment created by the SASP can lead to chronic inflammation, which can have detrimental affects on tissues and organs, contributing to various age-related diseases and conditions. JAK kinases contribute to the regulation of the SASP through the JAK/STAT pathway. We are developing "best-in-class" selective JAK2/3 and TYK2/JAK3 topical and systemically-delivered TKIs, discovered using our DEL screening technology, as senomorphic therapy, to down-regulate the SASP without the potential negative adverse..

Also known as: DELiver Therapeutics, Inc.

Primary location: Surfside United States