PEPTIDE SYNTHESIZERS

Titan 357 peptide synthesizers can produce hundreds of thousands to millions of peptides by the "mix-and-split" process described by Furka (Furka A, et al. Int. J. Peptide Protein Res. 1991, 37, 487). Matrix 357 peptide synthesizers produce resin-bound libraries in which each resin bead has a single discrete peptide. The number of different library components is limited mainly by the number of resin beads used to prepare the library. The entire library is screened by high-throughput screening procedures to find beads containing products of interest, then those products are identified by microsequencing or deconvolution methods... Peptide synthesizers Titan 357 and Matrix 384 utilize two different approaches to high throughput peptide synthesis. Titan 357 peptide synthesizers utilize combinatorial methodology developed by Furka to produce libraries containing vast numbers of peptides for screening. The Titan 357 produces a mixture of beads, each containing a discrete peptide. The..