MOLNOVA

MOLNOVA is a novel active small molecule and custom organic synthesis supplier. MOLNOVA provides 10,000+ Inhibitors, Agonists and Natural compounds with high purity and quality... Leukotrienes (LTs) are a class of mediators derived from arachidonic acid by the initiating activity of 5-lipoxygenase and 5-lipoxygenase-activating protein (FLAP). They are involved in self-defense systems against foreign bodies or microorganisms, but overproduction causes a variety of immune and inflammatory diseases. Two G protein-coupled receptors (GPCRs) have been cloned as receptors for leukotriene B4 (LTB4). The first, BLT1, known as a high-affinity LTB4 receptor, is expressed in various subsets of leukocytes and is responsible for LTB4-dependent leukocyte migration. The second, BLT2, was originally reported as a low-affinity LTB4 receptor and is now considered as a receptor for various oxidized fatty acids, including 12-hydroxyheptadecatrienoic acid (12-HHT) and hydroxyeicosatetraenoic acids (HETEs)...

Primary location: Ann Arbor United States