PROGRAM PEDIAC

Through these studies, we aim at identifying potentially preventable risk factors and novel markers of genetic predisposition to cancer. The comparison of tumors from patients with models reproducing more closely the situation found in patients will allow the identification of active molecular mechanisms specific to pediatric tumor cells... The overall goal of the project is centered around deciphering the mechanisms controlling the particular permissiveness and specificities of childhood to the development of pediatric cancers associated with poor prognosis . Our approach will be to exploit the existing epidemiological or genetic data to further identify risk factors, to generate new data using appropriate models allowing to characterize the importance and specificities of different developmental stages, to decipher the molecular mechanisms that control specific tumor cell initiation and maintenance and to improve modeling strategies to include the contribution of the tumor..

Primary location: Roubaix France