CKD-SYMPOSIUM

The condition develops when the kidneys are damaged and become unable to filter blood normally. Patients may experience problems associated with fluid, electrolytes, and waste build-up due to improper filtration, and the disease can increase the risk of developing heart disease... The current standard of care leaves patients open to the risks of inflammation and fibrosis, a largely unaddressed driver of CKD progression [3-5]... Finerenone is a selective antagonist of the mineralocorticoid receptor (MR). Activated by aldosterone and cortisol, the nonsteroidal MRA regulates gene transcription. The overexpression of the MR is believed to contribute to fibrosis and inflammation [6-7].

Primary location: Baierbrunn Germany