NANO4GLIO

The main objective of this project is to establish a new therapeutic approach for cancer treatment in general and for glioblastoma (GBM) in particular, a tumor for which there is no effective treatment. Novelty of the project relies not only on the use of RNAi technology (more specifically siRNA) to knock down selected proteins involved in tumoral cell survival and proliferation making them more susceptible to anticancer drugs and/or radiation but also on the use of novel cuttingedge multitasking nanoparticles (NPs). The specific siRNAs will be target-delivered by these NPs that will be fine-tuned in their structure and chemical surface to perform efficiently the tasks required for targeting an intracerebral glioblastoma xenograft: blood brain barrier crossing, siRNA target-delivered or tumor imaging... c) fine tuning of the 3D structure of the NPs based on feed-back from biological experiments

Primary location: Parkway United Kingdom