DENG LAB

Germ cells are often considered immortal. They are the sole messengers to relay genetic and epigenetic information across generations to perpetuate life. The germline cycle is long with specification starting from early gastrulation to gametogenesis continuing after birth. Errors occurring at any stage during this process can lead to devastating and long-lasting effects. With recent technological advances in single-cell sequencing, our knowledge of germline development in mammals has expanded considerably in recent times but some questions remain. Among them, we aim to answer (1) what regulates progenitor competence and then define cell quality to opt into germline specification? (2) How is migration correlated with epigenetic remodeling? (3) How certain genetic mutations affect gametogenesis?... Interestingly, two waves of epigenetic remodeling occur after fertilization to ensure the totipotency of the blastocyst for somatic lineage specification and to ascertain the "clean slate" of..

Also known as: The Deng Lab

Primary location: Stockholm Sweden