DYNAMIC CELL THERAPIES

Dynamic Cell Therapies is developing controllable CAR T cells to address difficult-to-treat cancers. Our platform technology of dynamic control of engineered T cells will improve the safety, efficacy, and durability of CAR T cell therapies. This system will have immediate applications in hematological cancers, with future approaches in solid tumors and autoimmune diseases... Our platform technology uncouples tumor targeting from CAR T cell activation. Each CAR T cell recognizes an inert small molecule. This small molecule is conjugated to a tumor-specific antibody. By dosing the small molecule-antibody conjugate, the physician can dynamically control CAR T cell activity and minimize the risk of life threatening side effects. Increasing the dose of the small molecule-antibody conjugate will strengthen the immune attack against tumor cells. In addition, the same small molecule can be coupled to different tumor targeting antibodies, allowing the physician to maximize on-target on-tumor..

Also known as: Dynamic Cell Therapies, Inc.

Primary location: Watertown United States