LIBERPHARMA
Updated 23 days ago
Liberpharma is engaged in the discovery and development of novel, small molecules for the treatment of diseases trough modification of lead compounds. Characterization techniques for elucidating the ligand-target structure include x-ray crystallography and nuclear magnetic resonance spectroscopy Lead compounds will be modified using high resolution computer modeling, medicinal- and computational[computing the energy of a particular molecular structure] chemistry Combinatorial chemistry will be used to produce the intended novel, highly specific small molecule compounds,needed for therapeutic benefits. First step is creating a low Ki value ,followed by adjusting for cell permeability, solubility [more hydrophile,lowering Log p],plasma stability,ADME, check Herg,Cytochrom etc [anti-gen]and toxicity The initial leads are proprietary chemical compounds