TAIFOL

TAIFOL aims to characterize the interactions between the abnormal B-cells and their immune TME. The heterogeneity of this immune TME will be grouped into four distinct scenarios based on the different clinical responses to standard chemo-immuno therapeutic regimens. We will use a mutiparametric approach using genomic, transcriptomic and imaging techniques. These results will provide the basis to design tailored immunotherapies directed to reactivate the immune system in each clinical subgroup that will be validated in state-of-the-art 3D cultures of FL patient's cells.