DEGU

Our goal is to use single-cell epigenomics technologies developed by our team to create cell-type-specific transcriptome and epigenome maps in frontal cortex and hippocampus associated with AD-like pathogenesis using two naturally occurring AD animal models: Octodon degus. The proposed research will allow us to develop a comparative analysis to determine conserved epigenetic alterations in the unconventional animal models and bridge our existing databases of mouse models and humans... Geographic variation comprises the comparison of populations of the same species located in different environments, i.e., places expected to have experienced different levels or types of selection. How organisms adapt to the ecological environmental challenges remains poorly understood. Furthermore, intraspecific geographic variation of behaviour, and its genetic determinism, has been little explored. The large latitudinal gradient in Chile provides a rich system for exploring these questions. Here we..

Also known as: degus-hub

Primary location: Du Et United States