CALCIOMICS

The objective of this research is to develop bioinformatics methods to predict and identify different classes of calcium binding sites in proteins based on key factors that contribute to calcium-binding affinity and the selectivity of proteins and calcium-dependent conformational change... In collaboration with faculty in the Georgia State University Department of Mathematics and Statistics, algorithms for predicting calcium binding sites based on structural and genomic information have been established using geometric, graphing, and statistical algorithms along with a web server containing up-to-date sequence, structure and literature information about calcium and its binding proteins in chemical, biological, and biomineralization. The Calcium Bank also provides putative calcium binding sites predicted in different genomes.