BALERIOLA

Although most localized mRNAs are believed to be transported to distal axons from the somatodendritic compartment, recent evidence suggests that some axonal transcripts might be delivered to axons by glial cells. Moreover, ribosomes and other translation regulators can be transferred to axons from neighbouring glia suggesting a non-cell-autonomous mechanism of local translation regulation in neurons. Among the mechanisms proposed for this horizontal transfer is their secretion by glia in intracellular vesicles (VEs) that are subsequently internalized into axons. Our aim is to determine the contribution of glial EVs in the ability of axons to translate proteins locally in models of amyloid-induced pathology. Ultimately, we wish to understand if EVs play a role in neurological disorders such Alzheimer´s disease, by regulating intra-axonal signaling events that require local translation.