PROTIBEA THERAPEUTICS

Alzheimer's Disease (AD) is best conceptualized as a process that plays out over decades resulting in immune activation, chronic neuroinflammation, metabolic dysregulation, the formation of amyloid beta plaques, excessive phosphorylation of tau proteins, disruption of synapse function and eventually neuron death. There is no single cause but rather a complex interaction of factors that are part of the process leading to chronic inflammation in the brain. Chronic inflammation (IL-1b, IL-6, TNF-a) is the essential common pathway leading to synaptic dysfunction, dementia and cell death... Any process predisposing to chronic neuroinflammation can lay claim to being a causal factor. Causal factors interact with one another and are best conceptualized through a systems biology approach utilizing a 3-dimensional network model progressing through time... We stress the importance of neuroinflammation, insulin resistance and elevated brain cortisol.

Also known as: Protibea Therapeutics Inc.