CHANG LAB

We are reverse-engineers. Our goal is to unravel the intricate mechanisms by which key regulatory components govern the complex gene regulation network. To accomplish this, we employ a combination of high-throughput biochemistry, bioinformatics data analysis, and machine learning to examine molecular mechanisms at a systems level... With a primary focus on developing large-scale experimental methods and novel data analytic toolchains, we strive to gain a more profound understanding of the quantitative nature of post-transcriptional gene regulation. By utilizing single-molecule-level measurements of various RNA states-including RNA modifications, chemical adducts, and poly(A) tail lengths-at a transcriptome scale, we can uncover the hidden rules shaped by multiple cis-regulatory factors.

Primary location: Seoul South Korea