SPP1923

The iden ti fi ca tion of a series of PRRs and RFs that con tribute to cell-autonomous immu ni ty against retro virus es pro vid ed a strong impe tus for the estab lish ment of the inter dis ci pli nary nation al research net work SPP1923. The over all goal of SPP1923 is to inte grate experts in retro vi rol o gy and innate immu ni ty to assem ble a nation al net work that address es key open ques tions on the inter play of retro virus es with the cell-autonomous immune sys tem of their hosts in col lab o ra tive projects. By these com bined efforts, we aim at the iden ti fi ca tion of the full mol e c u lar sens ing and restric tion machin ery involved, its reg u la tion, evolved virus-encod ed coun ter mea sures, and patho phys i o log i cal con se quences. Path o gen ic and apath o gen ic retro virus es will be inves ti gat ed in cell sys tems rang ing from mono typ ic cell cul tures to com plex ex vivo and ani mal mod els (Fig. 1). At these dif fer ent lev els of com plex i ty,..

Primary location: Germany