THE TING LAB

Traditional broad-spectrum antibacterial approaches have side effects to disrupt the beneficial microbiota in complex communities indiscriminately. This problem has led to the development of antimicrobials that can selectively target individual species or strains of bacteria. In recent work, we and others have developed programmable inhibitor cells (PICs) that direct the potent antibacterial activity of the T6SS against specified target cells. By introducing nanobodies on the surface of PICs to generate antigen-specific cell-cell adhesion, we could direct T6SS to efficiently deplete target cells in a multispecies environment without off-target activity. We aim to generalize the approach to better study ecological interactions in complex communities and the effects of dysbiosis... Bacteria colonize every habitat on earth. They impact ecosystems in diverse ways from preventing diseases on plant roots to altering nutrient uptake rate in the human gut. The influences are dependent on the..

Also known as: Ting Lab

Primary location: Taipei Taiwan