ANGIMMUNE

According to the CDC, in 2016, nearly 125,000 people in the United States started treatment for end-stage kidney disease, and more than 726,000 (2 in every 1,000 people) were on dialysis or were living with a kidney transplant. There are approximately 113,759 patients currently on the kidney transplant wait list, and this list is growing exponentially. Antibody mediated rejection is the leading cause of graft loss after kidney transplantation. Research in preclinical large animal models with analogs to Angimmune's human anti-CD3 rIT has led to the discovery of a novel, clinically relevant, therapeutic strategy for prevention of antibody mediated rejection following organ transplantation through the induction of stable B-cell tolerance. Unpublished animal data suggests that the unique properties of CD3 immunotoxin contribute to an immune regulatory response when combined with a proprietary transplantation induction protocol, resulting in stable B-cell tolerance induction. Angimmune is..

Also known as: Angimmune LLC