CHEMSYNBIO GROUP

Website of the ChemSynBio Group lead by Nediljko Budisa... Therefore, we are performing various organic syntheses, mainly of bioorthogonal amino acids, and investigate their effects on model peptides, proteins, protein-based complex scaffolds and whole cells (populations)... We were among the first groups who have used the Met analogues with selenium and tellurium-containing side chains for protein X-ray crystallography as well as to study and elucidate the mechanisms of folding and stability of proteins. For example, we made seminal contributions to understanding of the potential role of methionine oxidation in prion protein aggregation. In addition, we were among the first to use azide- and alkyne-containing Met analogues (originally developed by Dave Tirrell) for the "click" chemistry of proteins. Finally, we have pioneered in vivo metabolic engineering of Escherichia coli Met-biosynthetic pathways to generate diverse Met-like non-canonical amino acids that can be incorporated..

Primary location: Berlin Chile