YANG YANG

Our lab aims to advance pharmacogenomics and precision medicine to treat diseases of the nervous system (epilepsy, autism, dementia, and pain among others), promote functional recovery of the injured spinal cord/brain, and originate satisfactory solutions to manage cancer and its neurological complications... One main focus of the lab is on disorders related to the SCN2A genetic variants, recently discovered as a leading monogenic cause of autism and epilepsy. SCN2A gene encodes the voltage-gated sodium channel Nav1.2, mediating neuronal action potential firing in the central nervous system. We use mouse models and Human Induced Pluripotent Stem Cells (iPSCs) derived neuron, microglia, and brain organoid models for disease modeling and identifying disease mechanisms. We are developing next-generation therapeutics to tackle these disorders... We are hiring several postdocs, graduate students, and technicians to work on exciting projects funded by 5-year NIH R01s.

Primary location: West Lafayette United States