KAN KONSANTRELERI

Titanium represents an extremely bioinert material with excellent hydrophilic properties. In addition, titanium is resistant to corrosion and has the property of osteointegration. Because of this feature, it has been used in dental implants as well. Little is known about the blood compatibility of metals, but we know that titanium and derivatives thereof are among the most thrombogenic materials which may explain its outstanding osteointegrating properties. The coagulation activation caused by titanium was triggered by the intrinsic pathway because the generation of FXIIa-AT/C1 esterase inhibitor paralleled that of thrombin-antithrombin, and both thrombin-antithrombin complex and FXIIa-AT/C1 esterase inhibitor generation were abrogated by corn trypsin inhibitor, which is a specific inhibitor of FXIIa. The binding of platelets was increased on the titanium surface compared to the other biomaterial surfaces and the state of platelet activation was much more pronounced as reflected by the..