WASHINGTON UNIVERSITY IN ST. LOUIS

We found that inhibiting hepatocyte glucose transport and the adaptive responses that are engaged are sufficient to convey key aspects of the physiological response to caloric restriction. This includes upregulation of hepatic fat oxidation, autophagy and secretion of the anti-diabetic peptide - FGF21. Our goal is to understand and then utilize these responses to treat metabolic diseases, including non-alcoholic fatty liver disease, cardiovascular disease and type 2 diabetes mellitus... Welcome to the DeBosch lab The DeBosch laboratory uses mouse genetic, physiological, cell biological and multi-omic techniques to understand the sign...

Also known as: DeBosch, DeBosch Lab

Primary location: St. Louis United States