SCHUETTPELZLAB

The Schuettpelz lab studies how inflammation regulates hematopoietic stem cells (HSCs) and contributes to the development of hematopoietic malignancies. Inflammatory signals are important for the normal development of the immune system and the response to acute infection or injury, however sustained inflammatory signaling can impair HSC function. Furthermore, inflammatory signals can promote the clonal expansion of mutant HSCs and the development of hematopoietic malignancies. Understanding how both normal and mutant HSCs respond to inflammation is important for identifying strategies to optimize HSCs function and prevent blood cancers.

Also known as: Washington University in St. Louis

Primary location: St. Louis United States