CESTARI LAB

We study the signaling and regulatory processes that control the monogenic transcription of variant antigen genes and their periodic switching in expression, which is essential for antigenic variation in trypanosomes. We focus on how phosphoinositides regulate the machinery involved in gene silencing, transcriptional switching, and recombination... We are interested in the molecular and biophysical mechanisms that control the nuclear spatial organization and genome compartmentalization into transcriptionally active and silent regions. Moreover, we are interested in understanding the biogenesis and role of nuclear compartments in gene regulation... The Cestari Lab @ McGill investigates infectious diseases focusing on pathogens strategies of host immune evasion and vaccine development.

Primary location: Bellevue Canada