SMAHT

Much like mosaic artwork includes many different pieces that are similar but not the same, these somatic changes within our bodies create mosaics of cells in tissues. Some somatic changes are linked to cancer, but we know less about how somatic variants impact other disease processes. SMaHT aims to propel research into the processes that create somatic mosaicism and its clinical significance. Researchers in the SMaHT Network will identify a common set of human tissues (10-12) from multiple individuals (100-150) to study. This will include generating large-scale genomic datasets to characterize the landscape of somatic variants both within and across tissues, as well as performing analyses to better understand the mutational processes that result in somatic mosaicism... The Somatic Mosaicism across Human Tissues (SMaHT) Network aims to transform our understanding of how somatic mosaicism in human cells influences biology and disease.