ALZHEIMER

Project title Alzheimer's database Funding Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health About us Our goal is to expand the acquisition, processing/refinement, and immediate dissemination of a large-scale reference collection of 3D electron microscopic (EM) data, disclosing key ultrastructural details and thus advancing understanding of the hallmarks of neurodegeneration preserved within a collection of legacy biopsy brain samples (in our possession) from patients suffering from Alzheimer's Disease (AD). We have optimized the methods for performing this work through a 1-year NIH pilot award, and we are now collecting data, which is yielding important new details, with much higher throughput than prior methods. We propose to comprehensively target areas associated with both plaques and tangles, attending to locations where existing findings suggest cell and network vulnerability and contain molecular interactions suspected..

Primary location: La Jolla United States