MACIAS

Our research interest is focused on deciphering the mechanisms that correlate cell signaling with gene expression using high resolution structural biology. We also aim at discovering how these mechanisms are regulated, and their consequent implications in human diseases from the structural point of view. During the last decade, our work has been focused on the family of transcription factors Smads, and in their interaction with other cofactors and with DNA. Most projects related to TGF beta signalling and Smad functions, proteins and cofactors are carried out in collaboration with the group of Dr. J. Massagué (Sloan Kettering NY, USA).

Also known as: Macias Group

Primary location: Barcelona Spain