KIMATA LAB

Cell cycle regulators (CCRs) are well-known for their crucial role in controlling cell cycle progression. However, recent research, including our own, has revealed that some of these CCRs also have a direct impact on the cell fate decision and differentiation processes. By delving into these novel metazoan-specific functions of CCRs in various tissues of Drosophila, we aim to uncover their underlying mechanisms and roles. Additionally, we investigate their conserved roles in cultured human cells and tissues, paving the way for groundbreaking discoveries in the field of cell biology... Understanding the intricate interplay between cell proliferation, the cell cycle, and cellular differentiation is critical to unravelling the fundamental biology of multicellular organisms. Our research tackles this fundamental question by utilising the genetics of the multicellular model organism Drosophila melanogaster, together with advanced in vivo imaging, biochemistry, and multi-OMICs techniques...