MARGOLIS LAB - Key Persons
Job Titles:
- Admin
- Postdoctoral Fellow
Emily Cook is a third year graduate student in the BCMB Program at Hopkins. Originally from Philadelphia, she received her B.S. in Biological Sciences at the University of Pittsburgh. As an undergraduate, she worked with Jeff Brodsky studying chaperones involved in targeting proteins for Endoplasmic Reticulum Associated Degradation (ERAD). Following graduation, Emily worked in Dr. Richard Proia's lab at the NIH using iPSCs to generate disease models of the genetic disorders Sandhoff and Tay-Sachs. Since then, Emily's research interests have focused on genetic disorders affecting the brain. Upon joining the Margolis lab, Emily began working on a project to identify novel substrates of Ube3A, the protein mutated in Angelman Syndrome, a genetic neurodevelopmental disorder. Her work also aims to validate these substrates and evaluate relevant changes in substrates levels and/or function following loss of Ube3A. Outside of lab, Emily enjoys spending weekends at the beach with her family and binge watching crime shows on Netflix.
Fulya is a PhD candidate in the Biological Chemistry Graduate Program. She is from Istanbul, Turkey and attended Sabanci University in Istanbul where she was awarded a full scholarship based on a National University Entrance Exam score. Fulya received high honors at Sabanci University and was ranked the highest student in the Faculty of Engineering and Natural Sciences. Throughout the years, Fulya worked in several laboratories around the world. At Harvard Medical School with Dr. Carl Novina, Fulya had a middle authorship in Scientific Reports. For her thesis work, Fulya joined the Margolis laboratory in the Department of Biological Chemistry to study neuronal membrane proteasome (NMP)-derived peptides and their effects on classic activity-dependent signaling pathways. Her aim is to decipher to what extent these NMP peptides mediate changes that ultimately manifest into neuronal function. With some free time, Fulya likes to travel, spend time with her family and drink a large cup of coffee!
Job Titles:
- Graduate Student, Ph.D. 2018
Job Titles:
- Graduate Student, Ph.D. 2018
Job Titles:
- Graduate Student, Ph.D. 2017
Michael is a 2 nd year graduate student in the BCMB program. He is originally from Raleigh, North Carolina and completed his undergraduate degree in pharmaceutical science at North Carolina Central University where he also served as the Student Government Association (SGA), Student Body President. Throughout his undergrad career, he conducted research at his home institution and across the country at UNC Chapel Hill, Berkeley, Harvard, and Duke Clinical Research Institute. As a first-year graduate student Michael was awarded the NSF Graduate Research Fellowship (NSF GRFP) to fund his graduate education. In his free time, Michael enjoys reading, watching Netflix, and plotting his world domination. He is also Founder and CEO of the non-profit organization Black Scientists Matter Inc., an award-winning brand that is dedicated to empowering the Black community through science.
Job Titles:
- Assistant Professor
- Associate Professor
- Principal Investigator
Seth Margolis is an Assistant Professor in the Department of Biological Chemistry (Link to http://biolchem.bs.jhmi.edu/Pages/default.aspx )(primary appointment) and The Solomon H. Snyder Department of Neuroscience (Link to: http://neuroscience.jhu.edu ) (secondary appointment) in the Johns Hopkins University School of Medicine (Link to: http://www.hopkinsmedicine.org/som/index.html).
Seth received his PhD in cancer biology, working with Sally Kornbluth (Link to: http://pharmacology.mc.duke.edu/faculty/kornbluth.html) in the Department of Pharmacology and Cancer Biology at Duke University School of Medicine. As a graduate student Seth used biochemical and molecular approaches to decipher the protein signaling cascades critical for monitoring DNA responsive checkpoints that control timing of a cells transition into Mitosis (Link to graduate student publications). He switched fields and completed a postdoc in developmental neuroscience, working with Michael E. Greenberg (Link to: https://neuro.hms.harvard.edu/people/faculty/michael-greenberg) in the Department of Neurobiology at Harvard Medical School. There, Seth investigated the molecular and cellular events important for determining in development of the hippocampus when and to what extent excitatory synapses were forming (Link to postdoc publication). His postdoc research lead to the observation that critical players in the development of neuronal synapses are those that control the production and destruction of new proteins to maintain protein homeostasis. Seth moved to Johns Hopkins University School of Medicine in 2011 to start a laboratory using biochemical approaches to understand the molecular basis of protein homeostasis as it pertains to neuronal development in health and neurodevelopmental and neurodegenerative disease.
Seth loves to mentor students and just about anyone who walks into his office. Contact him by email smargol7@jhmi.edu or calling the office at (410) 502-5362.
Job Titles:
- Department of Biological Chemistry
Job Titles:
- Graduate Student, Ph.D. 2018